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Article

Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas.

Nature - 19 Jul 2001

Pasqualucci L, Neumeister P, Goossens T, Nanjangud G, Chaganti R S, Küppers R, Dalla-Favera R

Abstract excerpt

Genomic instability promotes tumorigenesis and can occur through various mechanisms, including defective segregation of chromosomes or inactivation of DNA mismatch repair. Although B-cell lymphomas are associated with chromosomal translocations that deregulate oncogene expression, a mechanism for genome-wide instability during lymphomagenesis has not been described. During B-cell development, the immunoglobulin...

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Share to B-Lymphocytes
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Lymphoma, Large B-Cell, Diffuse

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Source

Identifiers

PMID: 11460166
DOI: 10.1038/35085588

Genes

MYC
PAX5
PIM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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