Article
Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma.
Nature - 27 Jul 2011
Morin Ryan D, Mendez-Lago Maria, Mungall Andrew J, Goya Rodrigo, Mungall Karen L, Corbett Richard D, Johnson Nathalie A, Severson Tesa M, Chiu Readman, Field Matthew, Jackman Shaun, Krzywinski Martin, Scott David W, Trinh Diane L, Tamura-Wells Jessica, Li Sa, Firme Marlo R, Rogic Sanja, Griffith Malachi, Chan Susanna, Yakovenko Oleksandr, Meyer Irmtraud M, Zhao Eric Y, Smailus Duane, Moksa Michelle, Chittaranjan Suganthi, Rimsza Lisa, Brooks-Wilson Angela, Spinelli John J, Ben-Neriah Susana, Meissner Barbara, Woolcock Bruce, Boyle Merrill, McDonald Helen, Tam Angela, Zhao Yongjun, Delaney Allen, Zeng Thomas, Tse Kane, Butterfield Yaron, Birol Inanç, Holt Rob, Schein Jacqueline, Horsman Douglas E, Moore Richard, Jones Steven J M, Connors Joseph M, Hirst Martin, Gascoyne Randy D, Marra Marco A
Abstract excerpt
Follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) are the two most common non-Hodgkin lymphomas (NHLs). Here we sequenced tumour and matched normal DNA from 13 DLBCL cases and one FL case to identify genes with mutations in B-cell NHL. We analysed RNA-seq data from these and another 113 NHLs to identify genes with candidate mutations, and then re-sequenced tumour and matched normal DNA from these...
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