Molecular basis of chronic lymphocytic leukemia diagnosis and prognosis

doi:10.1007/s13402-014-0215-3

Article

Molecular basis of chronic lymphocytic leukemia diagnosis and prognosis

6 Jan 2015

Abstract excerpt

BACKGROUNDS: Chronic lymphocytic leukemia (CLL) is the most common type of leukemia in adults and is characterized by a clonal accumulation of mature apoptosis-resistant neoplastic cells. It is also a heterogeneous disease with a variable clinical outcome. Here, we present a review of currently known (epi)genetic alterations that are related to the etiology, progression and chemo-refractoriness of CLL. Relevant...

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