Article
TRAF1 gene polymorphism correlates with the titre of Gp210 antibody in patients with primary biliary cirrhosis.
Clinical & developmental immunology - 1 Jan 2012
Kempinska-Podhorodecka Agnieszka, Shums Zakera, Wasilewicz Michał, Wunsch Ewa, Milkiewicz Malgorzata, Bogdanos Dimitrios P, Norman Gary L, Milkiewicz Piotr
Abstract excerpt
BACKGROUND: Polymorphisms of TRAF1 (Tumor necrosis factor receptor-associated factor 1) are associated with rheumatoid arthritis (RA). Whether TRAF1 polymorphisms confer increased risk for primary biliary cirrhosis (PBC), an autoimmune liver disease which can co-exist with RA, is unknown. AIM OF THE STUDY: To assess the frequency of the RA-conferring susceptibility TRAF1 polymorphisms rs3761847 and rs2900180 in a...
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