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Article

Primary biliary cirrhosis shows association with genetic polymorphism of tumour necrosis factor alpha promoter region.

Journal of hepatology - 1 Aug 1999

Gordon M A, Oppenheim E, Camp N J, di Giovine F S, Duff G W, Gleeson D

Abstract excerpt

BACKGROUND/AIMS: Primary biliary cirrhosis is an autoimmune disease in which increased prevalence in first-degree relatives and an association with HLA DR8 suggest a genetic background. TNFalpha is a mediator of inflammation and immunity, and is implicated in the pathogenesis of primary biliary cirrhosis, ex vivo studies having shown reduced production of TNFalpha by lymphocytes from patients. Our group has...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HLA-DR Serological Subtypes

Share to Liver Cirrhosis, Biliary

Share to Polymorphism, Restriction Fragment Length

Share to Promoter Regions, Genetic

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Source

Identifiers

PMID: 10453936
DOI: 10.1016/s0168-8278(99)80220-7

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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