Article
Carriage of a tumor necrosis factor polymorphism amplifies the cytotoxic T-lymphocyte antigen 4 attributed risk of primary biliary cirrhosis: evidence for a gene-gene interaction.
Hepatology (Baltimore, Md.) - 1 Jul 2010
Juran Brian D, Atkinson Elizabeth J, Larson Joseph J, Schlicht Erik M, Liu Xiangdong, Heathcote E Jenny, Hirschfield Gideon M, Siminovitch Katherine A, Lazaridis Konstantinos N
Abstract excerpt
UNLABELLED: Common genetic variants significantly influence complex diseases such as primary biliary cirrhosis (PBC). We recently reported an association between PBC and a single nucleotide polymorphism (rs231725) of the immunoreceptor gene cytotoxic T-lymphocyte antigen 4 (CTLA4). We hypothesized that PBC risk attributed to this polymorphism might be increased by propensity to an overly robust inflammatory...
Topics
- Adult
- Aged
- Aged, 80 and over
- Antigens, CD
- CTLA-4 Antigen
- Female
- Humans
- Liver Cirrhosis, Biliary
- Male
- Middle Aged