Carriage of a tumor necrosis factor polymorphism amplifies the cytotoxic T-lymphocyte antigen 4 attributed risk of primary biliary cirrhosis: evidence for a gene-gene interaction.

doi:10.1002/hep.23667

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Article

Carriage of a tumor necrosis factor polymorphism amplifies the cytotoxic T-lymphocyte antigen 4 attributed risk of primary biliary cirrhosis: evidence for a gene-gene interaction.

Hepatology (Baltimore, Md.) - 1 Jul 2010

Juran Brian D, Atkinson Elizabeth J, Larson Joseph J, Schlicht Erik M, Liu Xiangdong, Heathcote E Jenny, Hirschfield Gideon M, Siminovitch Katherine A, Lazaridis Konstantinos N

Abstract excerpt

UNLABELLED: Common genetic variants significantly influence complex diseases such as primary biliary cirrhosis (PBC). We recently reported an association between PBC and a single nucleotide polymorphism (rs231725) of the immunoreceptor gene cytotoxic T-lymphocyte antigen 4 (CTLA4). We hypothesized that PBC risk attributed to this polymorphism might be increased by propensity to an overly robust inflammatory...

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PMID: 20578265
DOI: 10.1002/hep.23667
PMCID: PMC2922843

Genes

CTLA4
TNF

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