Article
Analysis of major histocompatibility complex and CTLA-4 alleles in Brazilian patients with primary biliary cirrhosis.
Journal of gastroenterology and hepatology - 1 Sept 2003
Bittencourt Paulo Lisboa, Palácios Selma Aliotti, Farias Alberto Queiroz, Abrantes-Lemos Clarice Pires, Cançado Eduardo Luiz Rachid, Carrilho Flair José, Laudanna Antonio Atílio, Kalil Jorge, Goldberg Anna C
Abstract excerpt
BACKGROUND AND AIMS: Predisposition to primary biliary cirrhosis (PBC) has been classically linked to HLA-DRB1 locus. However, the presence of the HLA-DRB1*08 antigen has been reported in less than one-third of PBC patients from Northern Europe and Japan. Recently, polymorphisms in the tumor necrosis factor alpha (TNFA) gene promoter at position -308 and in exon 1 of the cytotoxic T lymphocyte antigen-4 (CTLA-4)...
Topics
- Alleles
- Antigens, CD
- Antigens, Differentiation
- Brazil
- CTLA-4 Antigen
- Disease Progression
- Female
- HLA-DQ Antigens
- HLA-DR Antigens
- Humans
- Liver Cirrhosis, Biliary
- Male
- Middle Aged