The tumor necrosis factor-alpha promoter correlates with progression of primary biliary cirrhosis.

doi:10.1016/s0168-8278(99)80135-4

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Article

The tumor necrosis factor-alpha promoter correlates with progression of primary biliary cirrhosis.

Journal of hepatology - 1 May 1999

Tanaka A, Quaranta S, Mattalia A, Coppel R, Rosina F, Manns M, Gershwin M E

Abstract excerpt

BACKGROUND/AIMS: There have been many studies attempting to identify genes that determine susceptibility to primary biliary cirrhosis (PBC), but few studies have attempted to define the genes that modulate the natural history of the disease. There is a biallelic polymorphism, coined TNF1 and TNF2, in the TNFalpha promoter region at -308. We investigated the relative frequency of the TNF1 and TNF2 alleles in...

Topics

Alleles
California
DNA
Disease Progression
Genetic Carrier Screening
Genotype
Germany
Homozygote
Humans
Italy
Liver Cirrhosis, Biliary
Odds Ratio

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Polymorphism, Restriction Fragment Length

Promoter Regions, Genetic

Reference Values

Tumor Necrosis Factor-alpha

Victoria

Source

Open in PubMed

Identifiers

PMID: 10365808
DOI: 10.1016/s0168-8278(99)80135-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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