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Article

CTLA-4 gene polymorphism confers susceptibility to primary biliary cirrhosis.

Journal of hepatology - 1 Apr 2000

Agarwal K, Jones D E, Daly A K, James O F, Vaidya B, Pearce S, Bassendine M F

Abstract excerpt

BACKGROUND/AIM: Primary biliary cirrhosis (PBC) is an autoimmune cholestatic liver disease thought to develop through a complex interaction of genetic and environmental factors. It is characterised by T-cell-mediated non-suppurative destructive cholangitis. We have studied the polymorphic cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) gene, which encodes a molecule that is a vital negative regulator of...

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Source

Identifiers

PMID: 10782900
DOI: 10.1016/s0168-8278(00)80213-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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