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Article

Genetic variants of TRAF6 modulate peritoneal immunity and the risk of spontaneous bacterial peritonitis in cirrhosis: A combined prospective-retrospective study.

Scientific reports - 7 Jul 2017

Mai Martina, Stengel Sven, Al-Herwi Eihab, Peter Jack, Schmidt Caroline, Rubio Ignacio, Stallmach Andreas, Bruns Tony

Abstract excerpt

Alterations of the innate immunity contribute to the development of spontaneous bacterial peritonitis (SBP) in liver cirrhosis. Given its role in immune signaling, antimicrobial function, and macrophage differentiation, we hypothesized that genetic polymorphisms of TRAF6 modulate the risk of SBP. Thus, we determined theTRAF6 haplotype in 432 patients with cirrhosis and ascites using the haplotype-tagging single...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Urokinase Plasminogen Activator

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Source

Open in PubMed Open full text

Identifiers

PMID: 28687809
DOI: 10.1038/s41598-017-04895-z
PMCID: PMC5501819

Genes

TRAF6
CXCL8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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