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Article

Splenic Marginal Zone Granulocytes Acquire an Accentuated Neutrophil B-Cell Helper Phenotype in Chronic Lymphocytic Leukemia.

Cancer research - 15 Sept 2016

Gätjen Marcel, Brand Franziska, Grau Michael, Gerlach Kerstin, Kettritz Ralph, Westermann Jörg, Anagnostopoulos Ioannis, Lenz Peter, Lenz Georg, Höpken Uta E, Rehm Armin

Abstract excerpt

Recruitment of tumor-associated macrophages and neutrophils (TAM and TAN) to solid tumors contributes to immunosuppression in the tumor microenvironment; however, their contributions to lymphoid neoplasms are less clear. In human chronic lymphocytic leukemia (CLL), tumor B cells lodge in lymph nodes where interactions with the microenvironment occur. Tumor cell homing stimulates proliferation, such that...

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Identifiers

PMID: 27488528
DOI: 10.1158/0008-5472.CAN-15-3486

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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