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Article

Lack of TIR8/SIGIRR triggers progression of chronic lymphocytic leukemia in mouse models.

Blood - 21 Jul 2011

Bertilaccio Maria Teresa Sabrina, Simonetti Giorgia, Dagklis Antonis, Rocchi Martina, Rodriguez Tania Veliz, Apollonio Benedetta, Mantovani Alberto, Ponzoni Maurilio, Ghia Paolo, Garlanda Cecilia, Caligaris-Cappio Federico, Muzio Marta

Abstract excerpt

Inflammation is involved in the initiation and progression of several chronic lymphoid malignancies of B-cell type. Toll-like receptors (TLR) are transmembrane inflammatory receptors that on recognition of pathogen-associated molecular patterns trigger an innate immune response and bridge the inn...

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Topics

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Share to Antigens, CD19
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Transformation, Neoplastic

Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Share to Receptors, Interleukin-1

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Source

Identifiers

PMID: 21652674
DOI: 10.1182/blood-2011-01-329870

Genes

SIGIRR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21652674-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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