Characterization of the colorectal cancer-associated enhancer MYC-335 at 8q24: the role of rs67491583.

doi:10.1016/j.cancergen.2012.01.005

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Article

Characterization of the colorectal cancer-associated enhancer MYC-335 at 8q24: the role of rs67491583.

Cancer genetics - 1 Jan 2000

Tuupanen Sari, Yan Jian, Turunen Mikko, Gylfe Alexandra E, Kaasinen Eevi, Li Li, Eng Charis, Culver Daniel A, Kalady Matthew F, Pennison Michael J, Pasche Boris, Manne Upender, de la Chapelle Albert, Hampel Heather, Henderson Brian E, Marchand Loic Le, Hautaniemi Sampsa, Askhtorab Hassan, Smoot Duane, Sandler Robert S, Keku Temitope, Kupfer Sonia S, Ellis Nathan A, Haiman Christopher A, Taipale Jussi, Aaltonen Lauri A

Abstract excerpt

Recent genome-wide association studies have identified multiple regions at 8q24 that confer susceptibility to many cancers. In our previous work, we showed that the colorectal cancer (CRC) risk variant rs6983267 at 8q24 resides within a TCF4 binding site at the MYC-335 enhancer, with the risk allele G having a stronger binding capacity and Wnt responsiveness. Here, we searched for other potential functional...

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Identifiers

PMID: 22429595
DOI: 10.1016/j.cancergen.2012.01.005
PMCID: PMC3770308

Genes

MYC
GFI1
TCF4

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Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Research trail→

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Characterization of the colorectal cancer-associated enhancer MYC-335 at 8q24: the role of rs67491583.PMID 22429595Read ↗

Mice lacking a Myc enhancer that includes human SNP rs6983267 are resistant to intestinal tumors.Semantic proximity Read ↗

Upregulation of c-MYC in cis through a large chromatin loop linked to a cancer risk-associated single-nucleotide polymorphism in colorectal cancer cells.Semantic proximity Read ↗

The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling.Semantic proximity Read ↗

A Rare Missense Variant in TCF7L2 Associates with Colorectal Cancer Risk by Interacting with a GWAS-Identified Regulatory Variant in the MYC Enhancer.Semantic proximity Read ↗

The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer.Semantic proximity Read ↗

Scarless genome editing reveals risk SNP rs6983267-G and lncRNA CCAT2 dictate targetable PI3K signaling dependence in WNT-dysregulated CRCSemantic proximity Read ↗

Identification and characterization of functional risk variants for colorectal cancer mapping to chromosome 11q23.1.Semantic proximity Read ↗

Allelic imbalance at an 8q24 oncogenic SNP is involved in activating MYC in human colorectal cancer.Semantic proximity Read ↗

A polymorphic MYC response element in KBTBD11 influences colorectal cancer risk, especially in interaction with an MYC-regulated SNP rs6983267.Semantic proximity Read ↗

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