Article
Long-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA CARLo-5.
Proceedings of the National Academy of Sciences of the United States of America - 18 Mar 2014
Kim Taewan, Cui Ri, Jeon Young-Jun, Lee Ji-Hoon, Lee Ju Hee, Sim Hosung, Park Jong Kook, Fadda Paolo, Tili Esmerina, Nakanishi Hiroshi, Huh Man-Il, Kim Sung-Hak, Cho Ju Hwan, Sung Bong Hwan, Peng Yong, Lee Tae Jin, Luo Zhenghua, Sun Hui-Lung, Wei Huijun, Alder Hansjuerg, Oh Jeong Su, Shim Kang Sup, Ko Sang-Bong, Croce Carlo M
Abstract excerpt
The mechanism by which the 8q24 MYC enhancer region, including cancer-associated variant rs6983267, increases cancer risk is unknown due to the lack of protein-coding genes at 8q24.21. Here we report the identification of long noncoding RNAs named cancer-associated region long noncoding RNAs (CARLos) in the 8q24 region. The expression of one of the long noncoding RNAs, CARLo-5, is significantly correlated with...
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