Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Allelic imbalance at an 8q24 oncogenic SNP is involved in activating MYC in human colorectal cancer.

Annals of surgical oncology - 1 Dec 2014

Sugimachi Keishi, Niida Atsushi, Yamamoto Ken, Shimamura Teppei, Imoto Seiya, Iinuma Hisae, Shinden Yoshiaki, Eguchi Hidetoshi, Sudo Tomoya, Watanabe Masahiko, Tanaka Junichi, Kudo Shinei, Hase Kazuo, Kusunoki Masato, Yamada Kazutaka, Shimada Yasuhiro, Sugihara Kenichi, Maehara Yoshihiko, Miyano Satoru, Mori Masaki, Mimori Koshi

Abstract excerpt

BACKGROUND: The rs6983267 at 8q24.21 has been established as a significant cancer-related single nucleotide polymorphism (SNP). The risk allele showed similarity to the binding site of transcription factor TCF4/LEF1 that activates transcription of MYC. However, little is known about the role of this SNP in increasing MYC activity in colorectal cancers (CRCs). METHODS: The genotypes of rs6983267 in peripheral...

Read the complete abstract on PubMed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Tumor
Share to Chromosomes, Human, Pair 8
Share to DNA Copy Number Variations
Share to Gene Amplification
Share to Genes, myc
Share to Leukocytes, Mononuclear
Share to Loss of Heterozygosity
Share to Rectal Neoplasms

Source

Identifiers

PMID: 24390711
DOI: 10.1245/s10434-013-3468-6

Genes

MYC
TCF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Allelic imbalance at an 8q24 oncogenic SNP is involved in activating MYC in human colorectal cancer.PMID 24390711Read ↗

The rs6983267 SNP is associated with MYC transcription efficiency, which promotes progression and worsens prognosis of colorectal cancer.Semantic proximity Read ↗

The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling.Semantic proximity Read ↗

The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer.Semantic proximity Read ↗

Upregulation of c-MYC in cis through a large chromatin loop linked to a cancer risk-associated single-nucleotide polymorphism in colorectal cancer cells.Semantic proximity Read ↗

Review: Single nucleotide polymorphisms associated with the oncogenesis of colorectal cancer.Semantic proximity Read ↗

Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci.Semantic proximity Read ↗

Characterization of the colorectal cancer-associated enhancer MYC-335 at 8q24: the role of rs67491583.Semantic proximity Read ↗

Allelic imbalance at rs6983267 suggests selection of the risk allele in somatic colorectal tumor evolution.Semantic proximity Read ↗

Contribution of allelic imbalance to colorectal cancer.Semantic proximity Read ↗

A polymorphic MYC response element in KBTBD11 influences colorectal cancer risk, especially in interaction with an MYC-regulated SNP rs6983267.Semantic proximity Read ↗

Genetic variation in 8q24 associated with risk of colorectal cancer.Semantic proximity Read ↗

Cumulative evidence for relationships between multiple variants in 8q24 and colorectal cancer incidence.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.