Article

Scarless genome editing reveals risk SNP rs6983267-G and lncRNA CCAT2 dictate targetable PI3K signaling dependence in WNT-dysregulated CRC

2021-07-01

Abstract excerpt

<title>Abstract</title> <p>Genome-wide association studies have identified numerous loci associated with increased risk for colorectal cancer (CRC), including 8q24.21 which contains a known enhancer of proto-oncogene MYC . However, the role of candidate functional SNP rs6983267 within this locus remains unclear. Here, we generate isogenic cellular models of risk SNP rs6983267 in human CRC line, HCT-116. Comprehen...

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Literature Corpus work: 5f1c50c1-9e2b-5807-b81b-da0fc1a5673c
DOI: 10.21203/rs.3.rs-667797/v1

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