Article
The functional G143E variant of carboxylesterase 1 is associated with increased clopidogrel active metabolite levels and greater clopidogrel response.
Pharmacogenetics and genomics - 1 Jan 2013
Lewis Joshua P, Horenstein Richard B, Ryan Kathleen, O'Connell Jeffrey R, Gibson Quince, Mitchell Braxton D, Tanner Keith, Chai Sumbul, Bliden Kevin P, Tantry Udaya S, Peer Cody J, Figg William D, Spencer Shawn D, Pacanowski Michael A, Gurbel Paul A, Shuldiner Alan R
Abstract excerpt
INTRODUCTION: Carboxylesterase 1 (CES1) is the primary enzyme responsible for converting clopidogrel into biologically inactive carboxylic acid metabolites. METHODS: We genotyped a functional variant in CES1, G143E, in participants of the Pharmacogenomics of Anti-Platelet Intervention (PAPI) study (n=566) and in 350 patients with coronary heart disease treated with clopidogrel, and carried out an association...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.