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Article

The effects of CES1A2 A(-816)C and CYP2C19 loss-of-function polymorphisms on clopidogrel response variability among Chinese patients with coronary heart disease.

Pharmacogenetics and genomics - 1 Apr 2014

Xie Cheng, Ding Xiaoliang, Gao Jie, Wang Haipeng, Hang Yongfu, Zhang Hua, Zhang Jingjing, Jiang Bin, Miao Liyan

Abstract excerpt

OBJECTIVE: Carboxylesterase 1 hydrolyzes the majority of clopidogrel to the inactive metabolite. The aim of this study was to assess the effects of the CES1A2 A(-816)C polymorphism and other genetic and clinical factors on clopidogrel response variability. An additional aim was to investigate the...

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Source

Identifiers

PMID: 24535487
DOI: 10.1097/FPC.0000000000000035

Genes

VASP
ABCB1
PON1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24535487-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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