Effect of carboxylesterase 1 S75N on clopidogrel therapy among acute coronary syndrome patients.

doi:10.1038/s41598-017-07736-1

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Article

Effect of carboxylesterase 1 S75N on clopidogrel therapy among acute coronary syndrome patients.

Scientific reports - 3 Aug 2017

Xiao Fei-Yan, Luo Jian-Quan, Liu Min, Chen Bi-Lian, Cao Shan, Liu Zhao-Qian, Zhou Hong-Hao, Zhou Gan, Zhang Wei

Abstract excerpt

Carboxylesterase 1 (CES1) hydrolyzes the prodrug clopidogrel to an inactive carboxylic acid metabolite. The effects of CES1 S75N (rs2307240,C>T) on clopidogrel response among 851 acute coronary syndrome patients who came from the north, central and south of China were studied. The occurrence ratios of each endpoint in the CC group were significantly higher than in the CT + TT group for cerebrovascular events (14%...

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PMID: 28775293
DOI: 10.1038/s41598-017-07736-1
PMCID: PMC5543069

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CES1
MAF

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