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Article

Randomized evaluation of the loss-of-function carboxylesterase 1 (CES1) G143E variant on clopidogrel and ticagrelor pharmacodynamics.

Clinical and translational science - 1 Nov 2024

Lewis Joshua P, Ryan Kathleen A, Streeten Elizabeth A, Whitlatch Hilary B, Daue Melanie, Tanner Keith, Perry James A, O'Connell Jeffrey R, Shuldiner Alan R, Mitchell Braxton D

Abstract excerpt

Antiplatelet therapy with a P2Y12 receptor inhibitor, in combination with aspirin, is standard of care for medical management of patients with coronary artery disease, and flexibility in prescribing options among these medications offers great potential for individualizing patient care. Previously, we showed that a loss-of-function missense mutation (G143E) in carboxylesterase 1 (CES1), the primary enzyme...

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Share to Carboxylic Ester Hydrolases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39576732
DOI: 10.1111/cts.70079
PMCID: PMC11583987

Genes

CES1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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Randomized evaluation of the loss-of-function carboxylesterase 1 (CES1) G143E variant on clopidogrel and ticagrelor pharmacodynamics.PMID 39576732Read ↗

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