Article
IL-4 haplotype -590T, -34T and intron-3 VNTR R2 is associated with reduced malaria risk among ancestral indian tribal populations.
PloS one - 1 Jan 2012
Jha Aditya Nath, Singh Vipin Kumar, Kumari Namrata, Singh Ashish, Antony Justin, van Tong Hoang, Singh Sakshi, Pati Sudhanshu S, Patra Pradeep K, Singh Rajender, Toan Nguyen L, Song Le H, Assaf Amal, Messias-Reason Iara J T, Velavan Thirumalaisamy P, Singh Lalji, Thangaraj Kumarasamy
Abstract excerpt
BACKGROUND: Interleukin 4 (IL-4) is an anti-inflammatory cytokine, which regulates balance between T(H)1 and T(H)2 immune response, immunoglobulin class switching and humoral immunity. Polymorphisms in this gene have been reported to affect the risk of infectious and autoimmune diseases. METHODS: We have analyzed three regulatory IL-4 polymorphisms; -590C>T, -34C>T and 70 bp intron-3 VNTR, in 4216 individuals;...
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