Article
Genetic evidence of regulatory gene variants of the STAT6, IL10R and FOXP3 locus as a susceptibility factor in uncomplicated malaria and parasitaemia in Congolese children.
Malaria journal - 8 Jan 2013
Koukouikila-Koussounda Felix, Ntoumi Francine, Ndounga Mathieu, Tong Hoang V, Abena Ange-Antoine, Velavan Thirumalaisamy P
Abstract excerpt
BACKGROUND: Regulatory T cells (Tregs) are a subset of T cells that play an important role in modulating T effector responses during infectious challenges. The aim of this study was to evaluate possible associations between regulatory gene polymorphisms and the risk of uncomplicated malaria and the control of Plasmodium falciparum parasite density levels. METHODS: Twelve regulatory single nucleotide polymorphisms...
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