Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Correlation between the biochemical pathways altered by mutated parkinson-related genes and chronic exposure to manganese.

Neurotoxicology - 1 Sept 2014

Roth Jerome A

Abstract excerpt

The studies presented in this review attempt to describe the operative properties of the genes involved in generation of early and late onset of Parkinson's disease or Parkinson-like disorders and how mutation in these genes relate to onset of manganism. These include the genes α-synuclein, parkin, PINK1, DJ-1, ATP13A2, and SLC30A10 which are associated with early-onset of Parkinson's as well as those genes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Synuclein
Share to Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Manganese

Share to Oncogene Proteins

Share to Parkinsonian Disorders

Share to Protein Deglycase DJ-1

Share to Proton-Translocating ATPases

Share to Zinc Transporter 8

Source

Identifiers

PMID: 25149416
DOI: 10.1016/j.neuro.2014.08.006

Genes

PINK1
VPS35

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Correlation between the biochemical pathways altered by mutated parkinson-related genes and chronic exposure to manganese.PMID 25149416Read ↗

Are there common biochemical and molecular mechanisms controlling manganism and parkisonism.Semantic proximity Read ↗

Manganese-Induced Parkinsonism: Evidence from Epidemiological and Experimental Studies.Semantic proximity Read ↗

Manganese Neurotoxicity: A Comprehensive Review of Pathophysiology and Inherited and Acquired DisordersSemantic proximity Read ↗

Pathophysiology of manganese-associated neurotoxicity.Semantic proximity Read ↗

Genetic risk for Parkinson's disease correlates with alterations in neuronal manganese sensitivity between two human subjects.Semantic proximity Read ↗

α-Synuclein, leucine-rich repeat kinase-2, and manganese in the pathogenesis of parkinson diseaseSemantic proximity Read ↗

A multi-faceted genotoxic network of alpha-synuclein in the nucleus and mitochondria of dopaminergic neurons in Parkinson’s disease: Emerging concepts and challengesSemantic proximity Read ↗

Manganese Overexposure: Unveiling its Neurotoxic Potential and Involvement in Pathogenesis of Parkinson's DiseaseSemantic proximity Read ↗

Leads from xenobiotic metabolism genes for Parkinson's disease among north Indians.Semantic proximity Read ↗

Manganese-induced toxicity in normal and human B lymphocyte cell lines containing a homozygous mutation in parkin.Semantic proximity Read ↗

Manganese efflux in Parkinsonism: insights from newly characterized SLC30A10 mutations.Semantic proximity Read ↗

ATP13A2 (PARK9) polymorphisms influence the neurotoxic effects of manganese.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.