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Article

Manganese-Induced Parkinsonism: Evidence from Epidemiological and Experimental Studies.

Biomolecules - 30 Jul 2023

Lucchini Roberto, Tieu Kim

Abstract excerpt

Manganese (Mn) exposure has evolved from acute, high-level exposure causing manganism to low, chronic lifetime exposure. In this latter scenario, the target areas extend beyond the globus pallidus (as seen with manganism) to the entire basal ganglia, including the substantia nigra pars compacta. This change of exposure paradigm has prompted numerous epidemiological investigations of the occurrence of Parkinson's...

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PMID: 37627255
DOI: 10.3390/biom13081190
PMCID: PMC10452806

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