Mitochondrial Parkin Recruitment Is Impaired in Neurons Derived from Mutant PINK1 Induced Pluripotent Stem Cells

Abstract excerpt

Genetic Parkinson disease (PD) has been associated with mutations in PINK1, a gene encoding a mitochondrial kinase implicated in the regulation of mitochondrial degradation. While the studies so far examined PINK1 function in non-neuronal systems or through PINK1 knockdown approaches, there is an imperative to examine the role of endogenous PINK1 in appropriate human-derived and biologically relevant cell models....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Nuclear Receptors and Signaling
• Share to Parkinson's Disease Mechanisms and Treatments
• Share to Pluripotent Stem Cells Research