Article
Population-based sequencing of the V3-loop can predict the virological response to maraviroc in treatment-naive patients of the MERIT trial.
Journal of acquired immune deficiency syndromes (1999) - 1 Nov 2012
McGovern Rachel A, Thielen Alexander, Portsmouth Simon, Mo Theresa, Dong Winnie, Woods Conan K, Zhong Xiaoyin, Brumme Chanson J, Chapman Douglass, Lewis Marilyn, James Ian, Heera Jayvant, Valdez Hernan, Harrigan P Richard
Abstract excerpt
BACKGROUND: MERIT was a randomized trial comparing maraviroc (MVC) + Combivir versus efavirenz (EFV) + Combivir in drug-naive patients screened as having R5 HIV-1 by the original Trofile assay (OTA). We retrospectively evaluated treatment response after rescreening for viral tropism using population-based V3-loop sequencing. METHODS: HIV env V3-loop was amplified in triplicate using reverse...
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