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Article

Genotypic tropism testing by massively parallel sequencing: qualitative and quantitative analysis.

BMC medical informatics and decision making - 13 May 2011

Däumer Martin, Kaiser Rolf, Klein Rolf, Lengauer Thomas, Thiele Bernhard, Thielen Alexander

Abstract excerpt

BACKGROUND: Inferring viral tropism from genotype is a fast and inexpensive alternative to phenotypic testing. While being highly predictive when performed on clonal samples, sensitivity of predicting CXCR4-using (X4) variants drops substantially in clinical isolates. This is mainly attributed to minor variants not detected by standard bulk-sequencing. Massively parallel sequencing (MPS) detects single clones...

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Share to CXCR4 gene
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21569501
DOI: 10.1186/1472-6947-11-30
PMCID: PMC3112379

Genes

CXCR4
CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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