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Article

Genotypic analysis of the V3 region of HIV from virologic nonresponders to maraviroc-containing regimens reveals distinct patterns of failure.

Antimicrobial agents and chemotherapy - 1 Dec 2013

Swenson Luke C, Chui Celia K S, Brumme Chanson J, Chan Dennison, Woods Conan K, Mo Theresa, Dong Winnie, Chapman Doug, Lewis Marilyn, Demarest James F, James Ian, Portsmouth Simon, Goodrich James, Heera Jayvant, Valdez Hernan, Harrigan P Richard

Abstract excerpt

Changes in HIV tropism from R5 to non-R5 or development of drug resistance is often associated with virologic failure in patients treated with maraviroc, a CCR5 antagonist. We sought to examine changes in HIV envelope sequences and inferred tropism in patients who did not respond to maraviroc-based regimens. We selected 181 patients who experienced early virologic failure on maraviroc-containing therapy in the...

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Identifiers

PMID: 24080655
DOI: 10.1128/AAC.01534-13
PMCID: PMC3837924

Genes

CCR5
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Genotypic analysis of the V3 region of HIV from virologic nonresponders to maraviroc-containing regimens reveals distinct patterns of failure.PMID 24080655Read ↗

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