Article
Use of cellular HIV DNA to predict virologic response to maraviroc: performance of population-based and deep sequencing.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Jun 2013
Swenson Luke C, Dong Winnie W Y, Mo Theresa, Demarest James, Chapman Doug, Ellery Suzanne, Heera Jayvant, Valdez Hernan, Poon Art F Y, Harrigan P Richard
Abstract excerpt
BACKGROUND: A tropism test is required before administration of the antiretroviral drug maraviroc. However, plasma RNA testing is not possible in patients with undetectable plasma viral loads. Here we assess genotypic testing of cellular human immunodeficiency virus (HIV) DNA from peripheral blood mononuclear cells (PBMCs) to predict virologic responses in treatment-experienced patients beginning...
Topics
- Cyclohexanes
- DNA, Viral
- Genotype
- HIV
- HIV Fusion Inhibitors
- HIV Infections
- High-Throughput Nucleotide Sequencing
- Humans
- Kaplan-Meier Estimate
- Leukocytes, Mononuclear