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Article

Comparative determination of HIV-1 co-receptor tropism by Enhanced Sensitivity Trofile, gp120 V3-loop RNA and DNA genotyping.

Retrovirology - 30 Jun 2010

Prosperi Mattia C F, Bracciale Laura, Fabbiani Massimiliano, Di Giambenedetto Simona, Razzolini Francesca, Meini Genny, Colafigli Manuela, Marzocchetti Angela, Cauda Roberto, Zazzi Maurizio, De Luca Andrea

Abstract excerpt

BACKGROUND: Trofile is the prospectively validated HIV-1 tropism assay. Its use is limited by high costs, long turn-around time, and inability to test patients with very low or undetectable viremia. We aimed at assessing the efficiency of population genotypic assays based on gp120 V3-loop sequencing for the determination of tropism in plasma viral RNA and in whole-blood viral DNA. Contemporary and follow-up...

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Identifiers

PMID: 20591141
DOI: 10.1186/1742-4690-7-56
PMCID: PMC2907304

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Source receipt: pubmed, retrieved 7 Sept 2026.

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