Article
Correlation of the virological response to short-term maraviroc monotherapy with standard and deep-sequencing-based genotypic tropism prediction methods.
Antimicrobial agents and chemotherapy - 1 Mar 2012
Gonzalez-Serna A, McGovern R A, Harrigan P R, Vidal F, Poon A F Y, Ferrando-Martinez S, Abad M A, Genebat M, Leal M, Ruiz-Mateos E
Abstract excerpt
Genotypic tropism testing methods are emerging as the first step before prescription of the CCR5 antagonist maraviroc (MVC) to HIV-infected patients in Europe. Studies validating genotypic tests have included other active drugs that could have potentially convoluted the effects of MVC. The maraviroc clinical test (MCT) is an in vivo drug sensitivity test based on the virological response to a short-term exposure...
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