Frizzled 2 and frizzled 7 function redundantly in convergent extension and closure of the ventricular septum and palate: evidence for a network of interacting genes.

Abstract excerpt

Frizzled (Fz) 2 and Fz7, together with Fz1, form a distinct subfamily within the Frizzled family of Wnt receptors. Using targeted gene deletion, we show that: Fz7(-/-) mice exhibit tail truncation and kinking with 100% penetrance and ventricular septal defects (VSDs) with ~15% penetrance; Fz2(+/-);Fz7(-/-) mice exhibit VSDs with ~50% penetrance and cleft palate with less than 10% penetrance; and Fz2(-/-);Fz7(-/-)...

Topics

• Adaptor Proteins, Signal Transducing
• Animals
• Cell Line
• Cell Polarity
• Dishevelled Proteins
• Dogs
• Frizzled Receptors
• Gene Expression Regulation, Developmental
• HEK293 Cells
• Heart Septal Defects, Ventricular