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Article

Clarifying Frizzled 2 function in development through genetically validated mouse models.

Disease models & mechanisms - 1 Jul 2026

Michalski Megan N, Diegel Cassandra R, Zhong Zhendong A, Marshall Maddison E, Foxa Wiartalla Gabrielle E, Stevens Payton D, Suino-Powell Kelly, Blazer Levi L, Adams Jarrett J, Melcher Karsten, Sidhu Sachdev S, Angers Stephane, Williams Bart O

Abstract excerpt

Wnt receptors of the Frizzled (Fzd) family are widely considered to exhibit substantial functional redundancy, complicating efforts to therapeutically target individual receptors. Fzd2 was believed to be functionally redundant with Fzd1 and Fzd7, based on previously published global knockout mouse studies. By contrast, homozygosity for a Fzd2 global knockout mouse allele developed by the International Mouse...

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PMID: 42290195
DOI: 10.1242/dmm.052410
PMCID: PMC13446565

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