Article
The spontaneous mouse mutant low set ears (Lse) is caused by tandem duplication of Fgf3 and Fgf4.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Sept 2023
Luzzio Alana, Edie Sarah, Palmer Kristina, Caddle L Brianna, Urban Rachel, Goodwin Leslie O, Welsh Ian C, Reinholdt Laura G, Bergstrom David E, Cox Timothy C, Donahue Leah Rae, Murray Stephen A
Abstract excerpt
The external ear develops from an organized convergence of ventrally migrating neural crest cells into the first and second branchial arches. Defects in external ear position are often symptomatic of complex syndromes such as Apert, Treacher-Collins, and Crouzon Syndrome. The low set ears (Lse) spontaneous mouse mutant is characterized by the dominant inheritance of a ventrally shifted external ear position and...
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