Article

FRIZZLED 2 regulates limb development by mediating both β-catenin-dependent and independent Wnt signaling pathways

2022-09-09

Abstract excerpt

Human Robinow Syndrome and omodysplasia, characterized by skeletal limb and craniofacial defects, are associated with mutations in the Wnt receptor FZD2. However, as FZD2 can activate both canonical and non-canonical Wnt pathways, its precise functions and mechanisms of action in limb development are unclear. To address these questions, we generated mice harboring a single nucleotide insertion in the Dishevelled-i...

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Literature Corpus work: c5cd73ba-adbd-51d2-8549-27a835d4f0d9
DOI: 10.1101/2022.09.08.507207

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