Article
The nonmutagenic repair of broken replication forks via recombination.
Mutation research - 29 Dec 2002
Cox Michael M
Abstract excerpt
When replication forks stall or collapse at sites of DNA damage, there are two avenues for fork rescue. Mutagenic translesion synthesis by a special class of DNA polymerases can move a fork past the damage, but can leave behind mutations. The alternative nonmutagenic pathways for fork repair involve cellular recombination systems. In bacteria, nonmutagenic repair of replication forks may occur as often as once...
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