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Article

Grey matter correlates of clinical variables in amyotrophic lateral sclerosis (ALS): a neuroimaging study of ALS motor phenotype heterogeneity and cortical focality.

Journal of neurology, neurosurgery, and psychiatry - 1 Jul 2013

Bede Peter, Bokde Arun, Elamin Marwa, Byrne Susan, McLaughlin Russell L, Jordan Norah, Hampel Harald, Gallagher Laura, Lynch Catherine, Fagan Andrew J, Pender Niall, Hardiman Orla

Abstract excerpt

BACKGROUND: Body region of onset and functional disability are key components of disease heterogeneity in amyotrophic lateral sclerosis (ALS). OBJECTIVES: To evaluate patterns of grey matter pathology in the motor cortex and correlate focal structural changes with functional disability. METHODS: We conducted a single-centre neuroimaging study of a cohort of 33 cognitively normal patients with amyotrophic lateral...

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PMID: 23085933
DOI: 10.1136/jnnp-2012-302674

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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