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Article

Regional spreading pattern is associated with clinical phenotype in amyotrophic lateral sclerosis.

Brain : a journal of neurology - 3 Oct 2023

Maranzano Alessio, Verde Federico, Colombo Eleonora, Poletti Barbara, Doretti Alberto, Bonetti Ruggero, Gagliardi Delia, Meneri Megi, Maderna Luca, Messina Stefano, Corti Stefania, Morelli Claudia, Silani Vincenzo, Ticozzi Nicola

Abstract excerpt

Increasing evidence shows that disease spreading in amyotrophic lateral sclerosis (ALS) follows a preferential pattern with more frequent involvement of contiguous regions from the site of symptom onset. The aim of our study was to assess if: (i) the burden of upper (UMN) and lower motor neuron (LMN) involvement influences directionality of disease spreading; (ii) specific patterns of disease progression are...

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Identifiers

PMID: 37075222
DOI: 10.1093/brain/awad129
PMCID: PMC10545526

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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