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Article

Cerebral cortex and the clinical expression of Huntington's disease: complexity and heterogeneity.

Brain : a journal of neurology - 1 Apr 2008

Rosas H Diana, Salat David H, Lee Stephanie Y, Zaleta Alexandra K, Pappu Vasanth, Fischl Bruce, Greve Doug, Hevelone Nathanael, Hersch Steven M

Abstract excerpt

The clinical phenotype of Huntington's disease (HD) is far more complex and variable than depictions of it as a progressive movement disorder dominated by neostriatal pathology represent. The availability of novel neuro-imaging methods has enabled us to evaluate cerebral cortical changes in HD, which we have found to occur early and to be topographically selective. What is less clear, however, is how these...

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Identifiers

PMID: 18337273
DOI: 10.1093/brain/awn025
PMCID: PMC2657201

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