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Article

Cytochrome P450 2C9 variants influence response to celecoxib for prevention of colorectal adenoma.

Gastroenterology - 1 Jun 2009

Chan Andrew T, Zauber Ann G, Hsu Meier, Breazna Aurora, Hunter David J, Rosenstein Rebecca B, Eagle Craig J, Hawk Ernest T, Bertagnolli Monica M

Abstract excerpt

BACKGROUND & AIMS: Variants in the cytochrome P450 2C9 (CYP2C9) gene are associated with impaired metabolism of celecoxib. We examined the influence of CYP2C9*2 (R144C) and CYP2C9*3 (I359L) variants on dose-related response or toxicity in a randomized trial of celecoxib. METHODS: We identified individuals with CYP2C9*2 and CYP2C9*3 genotypes (>or=1 variant allele) in the Adenoma Prevention with Celecoxib trial....

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Identifiers

PMID: 19233181
DOI: 10.1053/j.gastro.2009.02.045
PMCID: PMC2693443

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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