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Article

Association of CYP2C9 genotypes leading to high enzyme activity and colorectal cancer risk.

Carcinogenesis - 1 Aug 2001

Martínez C, García-Martín E, Ladero J M, Sastre J, Garcia-Gamito F, Diaz-Rubio M, Agúndez J A

Abstract excerpt

CYP2C9 enzyme activity is involved in the metabolism of substances related to colorectal cancer, and it is functionally linked to a genetic polymorphism. Two allelic variants of the CYP2C9 gene, namely CYP2C9*2 and CYP2C9*3, differ from wild-type CYP2C9*1 by single amino acid substitutions. These mutated alleles encode enzymes with altered properties that are associated with impaired metabolism. The present study...

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Identifiers

PMID: 11470765
DOI: 10.1093/carcin/22.8.1323

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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