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Article

A prospective study of genetic polymorphisms in the cytochrome P-450 2C9 enzyme and the risk for distal colorectal adenoma.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Aug 2004

Chan Andrew T, Tranah Gregory J, Giovannucci Edward L, Hunter David J, Fuchs Charles S

Abstract excerpt

BACKGROUND & AIMS: Regular aspirin use is associated with a reduced risk for colorectal adenoma, whereas smoking increases risk. The cytochrome P-450 (CYP) 2C9 (CYP2C9) enzyme is involved in the metabolism of several drugs, including possibly aspirin, and such carcinogens as smoking-related polycyclic aromatic hydrocarbons. Genetic variation in this enzyme may modulate the influence of aspirin and smoking on...

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Identifiers

PMID: 15290664
DOI: 10.1016/s1542-3565(04)00294-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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