Article
Common genetic polymorphisms in the 5'-flanking region of the SULT1A1 gene: haplotypes and their association with platelet enzymatic activity.
Pharmacogenetics and genomics - 1 Jul 2005
Ning Baitang, Nowell Susan, Sweeney Carol, Ambrosone Christine B, Williams Suzanne, Miao Xiaoping, Liang Gang, Lin Dongxin, Stone Angie, Ratnasinghe D Luke, Manjanatha Mugimane, Lang Nicholas P, Kadlubar Fred F
Abstract excerpt
SULT1A1 is a phase II detoxification enzyme involved in the biotransformation of a wide variety of endogenous and exogenous phenolic compounds. Human platelet SULT1A1 enzymatic activity shows marked inter-individual variability and a common coding polymorphism, SULT1A1*1/*2, has been described that accounts for a proportion of this variability. We examined the 5'-flanking region of the SULT1A1 gene to determine...
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