Article
Haplotype structure of the UDP-glucuronosyltransferase 1A1 promoter in different ethnic groups.
Pharmacogenetics - 1 Dec 2002
Innocenti Federico, Grimsley Carrie, Das Soma, Ramírez Jacqueline, Cheng Cheng, Kuttab-Boulos Hala, Ratain Mark J, Di Rienzo Anna
Abstract excerpt
Genetic variation in UDP-glucuronosyltransferase 1A1 (UGT1A1)expression has several important clinical implications. UGT1A1 basal transcription is affected by a polymorphic (TA)n repeat, and another important regulatory element is the phenobarbital-responsive enhancer module (PBREM) which might contain variants affecting inducible gene expression. We assessed the extent of linkage disequilibrium between the (TA)n...
Topics
- Black or African American
- Base Sequence
- Bilirubin
- Camptothecin
- Genotype
- Glucuronides
- Glucuronosyltransferase
- Haplotypes
- Humans
- Irinotecan
- Linkage Disequilibrium