Article

Large-Scale Hypothesis Testing for Causal Mediation Effects with Applications in Genome-wide Epigenetic Studies

2020-09-23

Abstract excerpt

In genome-wide epigenetic studies, it is of great scientific interest to assess whether the effect of an exposure on a clinical outcome is mediated through DNA methylations. However, statistical inference for causal mediation effects is challenged by the fact that one needs to test a large number of composite null hypotheses across the whole epigenome. Two popular tests, the Wald-type Sobel’s test and the joint si...

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Literature Corpus work: 509a793b-eba2-524f-b2e8-54a8629fe9c7
DOI: 10.1101/2020.09.20.20198226

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