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Article

Contribution of large region joint associations to complex traits genetics.

PLoS genetics - 1 Apr 2015

Paré Guillaume, Asma Senay, Deng Wei Q

Abstract excerpt

A polygenic model of inheritance, whereby hundreds or thousands of weakly associated variants contribute to a trait's heritability, has been proposed to underlie the genetic architecture of complex traits. However, relatively few genetic variants have been positively identified so far and they collectively explain only a small fraction of the predicted heritability. We hypothesized that joint association of...

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PMID: 25856144
DOI: 10.1371/journal.pgen.1005103
PMCID: PMC4391841

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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