Genetic architecture reconciles linkage and association studies of complex traits.

doi:10.1038/s41588-024-01940-2

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Article

Genetic architecture reconciles linkage and association studies of complex traits.

Nature genetics - 1 Nov 2024

Sidorenko Julia, Couvy-Duchesne Baptiste, Kemper Kathryn E, Moen Gunn-Helen, Bhatta Laxmi, Åsvold Bjørn Olav, Mägi Reedik, Ani Alireza, Wang Rujia, Nolte Ilja M, Gordon Scott, Hayward Caroline, Campbell Archie, Benjamin Daniel J, Cesarini David, Evans David M, Goddard Michael E, Haley Chris S, Porteous David, Medland Sarah E, Martin Nicholas G, Snieder Harold, Metspalu Andres, Hveem Kristian, Brumpton Ben, Visscher Peter M, Yengo Loic

Abstract excerpt

Linkage studies have successfully mapped loci underlying monogenic disorders, but mostly failed when applied to common diseases. Conversely, genome-wide association studies (GWASs) have identified replicable associations between thousands of SNPs and complex traits, yet capture less than half of the total heritability. In the present study we reconcile these two approaches by showing that linkage signals of...

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PMID: 39375568
DOI: 10.1038/s41588-024-01940-2

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