Article

GCL pruning of PIP3 establishes the soma-germline boundary

2025-12-31

Abstract excerpt

Primordial germ cells (PGCs) are the first cells specified in the Drosophila embryo and serve as precursors to the germline. Their formation requires suppression of somatic fates, a process achieved by excluding the receptor tyrosine kinase Torso from the posterior pole through degradation mediated by the ubiquitin ligase adaptor Germ Cell-Less (GCL). Although Torso is known to antagonize PGC formation, the underl...

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Literature Corpus work: 3952742a-96c5-5743-9df0-2132a13edfd1
DOI: 10.64898/2025.12.30.697122

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