Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Coactivation of STAT and Ras is required for germ cell proliferation and invasive migration in Drosophila.

Developmental cell - 1 Nov 2003

Li Jinghong, Xia Fan, Li Willis X

Abstract excerpt

Primordial germ cells (PGCs) undergo proliferation, invasion, guided migration, and aggregation to form the gonad. Here we show that in Drosophila, the receptor tyrosine kinase Torso activates both STAT and Ras during the early phase of PGC development, and coactivation of STAT and Ras is required for PGC proliferation and invasive migration. Embryos mutant for stat92E or Ras1 have fewer PGCs, and these cells...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Embryo, Nonmammalian
Share to Germ Cells
Share to GTP-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Janus Kinases

Share to Mitosis

Share to Protein-Tyrosine Kinases

Share to Receptor Protein-Tyrosine Kinases

Share to STAT Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 14602078
DOI: 10.1016/s1534-5807(03)00328-9
PMCID: PMC3092433

Genes

PGC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Coactivation of STAT and Ras is required for germ cell proliferation and invasive migration in Drosophila.PMID 14602078Read ↗

Discrete somatic niches coordinate proliferation and migration of primordial germ cells via Wnt signalingSemantic proximity Read ↗

GCL pruning of PIP3 establishes the soma-germline boundarySemantic proximity Read ↗

Drosophila gain-of-function mutant RTK torso triggers ectopic Dpp and STAT signaling.Semantic proximity Read ↗

A transitory signaling center controls timing of primordial germ cell differentiationSemantic proximity Read ↗

Ror2 enhances polarity and directional migration of primordial germ cells.Semantic proximity Read ↗

A functional antagonism between the pgc germline repressor and torso in the development of somatic cells.Semantic proximity Read ↗

Primordial germ cell proliferation is impaired in Fused Toes mutant embryos.Semantic proximity Read ↗

RNA-binding protein TIAR is essential for primordial germ cell developmentSemantic proximity Read ↗

Expression and function of clift in the development of somatic gonadal precursors within the Drosophila mesoderm.Semantic proximity Read ↗

Niche cells regulate primordial germ cell quiescence in response to basement membrane signalingSemantic proximity Read ↗

Primordial germ cells and gastrointestinal stromal tumors respond distinctly to a cKit overactivating allele.Semantic proximity Read ↗

Paracrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial cells in Drosophila.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.