Article
A knock-in mouse model of gastrointestinal stromal tumor harboring kit K641E.
Cancer research - 1 Aug 2005
Rubin Brian P, Antonescu Cristina R, Scott-Browne James P, Comstock Melissa L, Gu Yansong, Tanas Munir R, Ware Carol B, Woodell Jessica
Abstract excerpt
A mouse model of gastrointestinal stromal tumor (GIST) has been developed by a knock-in gene targeting strategy, which introduced a Kit gene K641E mutation, originally identified in sporadic human GISTs and in the germ line of familial GIST syndrome patients. Homozygous and heterozygous Kit K641E mice develop gastrointestinal pathology with complete penetrance and all Kit K641E homozygotes die by age 30 weeks due...
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